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KMID : 0384320090300010023
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Korean Journal of Family Medicine
2009 Volume.30 No. 1 p.23 ~ p.30
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Association of serum gamma glutamyltransferase and fasting blood glucose among middle aged and elderly in Chuncheon : Hallym Aging Study
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Lim Jung-Su
Choi Young-Ho
Jeong Jin-Young
Jang Soong-Nang
Moon Yoo-Sun
Kim Jung-Hun
Kwak Eun-Shin
Choi Moon-Gi
Hong Kyung-Soon
Kim Dong-Hyun
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Abstract
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Background: Serum gamma-glutamyltransferase (GGT) was reported to be associated with type 2 diabetes, many cardiovascular disease risk factors, and individual components of metabolic syndrome. We performed a cross-sectional study to elucidate the relations between GGT and impaired fasting glucose (IFG).
Methods: The subject of this study included 693 adults (males 272, females 421) aged 45 years or over who have lived in Chuncheon, suburban small-sized city. IFG was defined by an elevated fasting plasma glucose (FPG) concentration (≥100 and < 126 mg/dl).
Results: The risk of IFG appeared to increase with increasing levels of serum GGT even after adjusting for other covariates, such as body mass index and inflammatory markers among men only: Adjusted odds ratios of IFG across GGT categories (<25th, <50th, <75th and ≥75th) were 1.0, 0.56, 1.57, 2.79. (p-value for trend 0.022). In women, the association between the risk of IFG and GGT was not statistically significant.
Conclusion: This study suggests that elevated level of GGT within the normal range is a independent predictor of impaired fasting glucose in middle-ages or older men but not in women.
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KEYWORD
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Gamma-glutamyltransferase, Impaired fasting glucose, Insulin resistance
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